The second blight on the "grapes" was pleasure-seeking. In Isaiah"s day this vice manifested itself in drinking too much wine and strong drink, usually at a continuous round of parties (cf. Isaiah 22:13; Isaiah 28:1-8; Hosea 7:5; Joel 3:3; Amos 6:6). These people were "party animals" who paid no attention to the Lord or His works. Seeking pleasure is not wrong in itself unless it becomes too absorbing, as it had with many Israelites. Too much partying produces insensitivity to spiritual things. [source][source][source]
"When the passion for pleasure has become uppermost in a person"s life, passion for God and his truth and his ways is squeezed out." [1][source]