Paul then turned his attention north and proposed to enter the province of Bithynia. It lay along the southern shores of the Black Sea and contained many Roman cities and Jewish colonies. Mysia was another geographical region such as Phrygia located in northwest Asia "through" (Gr. parelthontes, not "by," Acts 16:8) which Paul"s party passed to get to Bithynia. Again the Holy Spirit, whom Luke here called "the Spirit of Jesus" (cf. Acts 1:1-2), prevented their entering that province. This unusual title of the Holy Spirit highlights Jesus" leadership in the mission. Other unidentified Christian missionaries evangelized Bithynia (cf. 1 Peter 1:1). [1][source]
Consequently Paul turned west from where he was and proceeded to Troas. This city was a Roman colony, like Antioch of Pisidia and Lystra, located at a very strategic site. It was one of the main seaports from which travelers entered Asia Minor from the West and departed from Asia Minor for the Roman provinces farther west. It was about25 miles south of ancient Troy and585 miles from Antioch of Syria. [source][source][source]
"To the Greeks, mountains protected but separated people, whereas the sea, while frightening, united people. Therefore Troas, at the mouth of the Dardenelles, was the pivotal port between the land masses of Europe and Asia Minor and the great waterways of the Aegean and Black seas." [2][source]